ABSTRACT
PURPOSE: We evaluated the hemodynamic statuses of patients after partial closure of atrial septal defects with fenestration due to pulmonary hypertension. MATERIALS AND METHODS: Seventeen adult patients underwent partial atrial septal defect closure and follow-up cardiac catheterization. We analyzed hemodynamic data and clinical parameters before and after closure. RESULTS: The median age at closure was 29 years old. The baseline Qp/Qs was 1.9+/-0.6. The median interval from the operation to the cardiac catheterization was 27 months. The CT ratio decreased from 0.55+/-0.07 to 0.48+/-0.06 (p<0.05). The mean pulmonary arterial pressure decreased from 50.0+/-11.5 mm Hg to 32.5+/-14.4 mm Hg (p<0.05), and the pulmonary resistance index decreased from 9.2+/-3.6 Wood units*m2 to 6.3+/-3.8 Wood units*m2 (p<0.05). Eleven patients (64.7%) continued to exhibit high pulmonary resistance (over 3.0 Wood units*m2) after closure. These patients had significantly higher pulmonary resistance indices and mean pulmonary arterial pressures based on oxygen testing before the partial closures (p<0.05). However, no significant predictors of post-closure pulmonary hypertension were identified. CONCLUSION: Despite improvement in symptoms and hemodynamics after partial closure of an atrial septal defect, pulmonary hypertension should be monitored carefully.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Cardiac Catheterization/adverse effects , Follow-Up Studies , Heart Defects, Congenital/epidemiology , Heart Septal Defects, Atrial/surgery , Hemodynamics/physiology , Hypertension, Pulmonary/diagnosis , Oxygen , Postoperative Complications/diagnosis , Retrospective Studies , Treatment OutcomeABSTRACT
Objective To know the effects of partial closure combined with MgSO_4 hydropathic com-press for injury because of highly irritating drugs extravasation. Methods Divided 144 patients with injury because of highly irritating drugs extravasation into the treatment group and the control group randomly, there were 72 cases in each group. 50% MgSO_4 was used in the control gnmp, partial closure was used in the treat-ment group in addition. Compared the medical effects between the two groups. Results Compared with the control group, the medical effects of injury because of highly irritating drugs extravasation in the treat-ment group was better. Conclusions Partial closure combined with MgSO_4 hydropathic compress is a kind of effective method for patients with injury because of highly irritating drugs extravasation, which can quickly promote absort by surrounding tissue and release pains.